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Primary small cell carcinoma of the ureter with associated hyponatremia and rapid progression to bladder involvement: a case report
African Journal of Urology volume 28, Article number: 24 (2022)
Primary small cell carcinoma (SmCCa) of the ureter is rare. The majority of patients present with visible haematuria. Diagnosis is confirmed by histopathology. Associated hyponatraemia in GU lesion can be due SmCCa can be useful for early diagnosis aggressive ureteric tumors. The current management includes radical surgery or radiotherapy with concomitant chemotherapy to improve survival and quality of life.
We present a case of a 77 years female who was found to have unilateral hydronephrosis with a 5 cm filling defect in the distal ureter on CT urogram. Further staging showed organ-confined disease. Serum sodium levels were low at presentation. At the time of planned nephroureterectomy (NU), cystoscopy revealed a bladder tumor obstructing the right ureteric orifice. TURBT was performed instead. After TURBT, there was marked hyponatremia and histology was small cell carcinoma (SmCCa). Paraneoplastic SIADH was the likely cause. Neoadjuvant chemotherapy (NACT) followed by radiotherapy (RT) was chosen for definitive treatment. This resulted in an excellent response supported by radiological evidence of almost complete resolution of the tumor.
The presence of genitourinary lesion and hyponatremia should raise suspicion of paraneoplastic SIADH. The case suggests the emphasis of histological diagnosis of the genitourinary lesion with existing hyponatraemia to provide better outcome with NACT followed by definitive treatment. We share our experience of NACT and RT in the management of ureteric SmCCa extension to the bladder.
Primary small cell carcinoma (SmCCa) of the genitourinary (GU) tract is rare, accounting for less than 0.5% of all GU tumors . SmCCa of the bladder accounts for less than 1% of all bladder cancers while SmCCa of the ureter is extremely rare . Presentation of SmCCa of GU tract is no different from urothelial carcinoma. Ninety percent of the patients present with painless gross haematuria [1, 2]. Due to its aggressive nature, the prognosis of the disease is poor.
Diagnosis is usually confirmed by histopathological examination. The paraneoplastic syndrome can be a presenting or associated feature in patients with SmCCa. Syndrome of inappropriate anti-diuretic hormone secretion (SIADH) in SmCCa of the lungs is well established but uncommon in extrapulmonary SmCCa . There is no standard agreed management approach for GU SmCCa, however, multimodal treatment with chemotherapy and radical surgery or radiotherapy is the mainstay to improve survival and quality of life.
We report a case of SmCCa of the ureter which rapidly progressed to involve the bladder. Our patient had associated hyponatraemia at presentation and throughout the evaluation course, which was due to paraneoplastic SIADH.
A fit 77, non-smoker, female was evaluated for intermittently painless visible haematuria. There were no co-morbidities or psychological issues. She did not have previous genetic analysis in view of no family history of cancers. General physical and abdominal examination was unremarkable. Flexible cystoscopy showed a normal bladder but oozing of blood from the right ureteric orifice. Serum creatinine and serum sodium at presentation was 66 mmol/L (eGFR > 60) and 126 mmol/L, respectively. She had no symptoms related to hyponatraemia at presentation. CT urogram (CTU) showed marked right hydronephrosis and hydroureter with a filling defect of 5 cm just above the vesicoureteric junction (Fig. 1). The urology multidisciplinary team meeting concluded that features were consistent with malignant neoplastic ureteric lesion and staging CT chest, abdomen, and pelvis (CAP) showed no evidence of metastasis or lymphadenopathy. In view of large ureteric lesion, normal renal functions and after full discussion of risk and benefits of surgical management, nephroureterectomy was planned.
Rigid cystoscopy at the time of planned right nephroureterectomy (6 weeks from the date of diagnosis) revealed a large lesion at the bladder base and right bladder wall. These findings suggested rapid extension of ureteric tumor in the bladder due to aggressive tumor. Both ureteric orifices were not visible, and a limited transurethral resection of bladder tumor (TURBT) was performed.
The histological features revealed a high-grade (G3) muscle invasive neuroendocrine small cell carcinoma. There was variable staining for cytokeratins, exhibiting dot like cytoplasmic staining for broad spectrum cytokeratins (AE1/3) but negative for another cytokeratin stain (MNF) as well for GATA3. The tumor cells were positive for synaptophysin and there was focal weak staining for CD56. The tumor was negative for TTF1 and CD45. (Fig. 2).
Subsequently, re-staging showed worsening hydronephrosis and a large mass measuring 4.2 × 5.2 × 4.2 cm in the right posterior-lateral wall of the urinary bladder infiltrating into the perivesical fat consistent with the T3N0M0 stage of the disease (Fig. 3).
The patient developed marked hyponatraemia after TURBT (serum sodium of 117 mmol/L, serum osmolarity of 251 mmol/kg, urine sodium of 20 mmol/L and urine osmolarity 123 mmol/kg). The patient was euvolemic and had no neurological symptoms. Serum sodium levels improved to 129 mmol/kg with fluid restriction. Before presentation with visible haematuria, sodium levels were within the normal range. A decline in serum sodium levels from the normal ranges was seen since the onset of symptoms (Fig. 4). Serum cortisol and thyroid hormone levels were within the normal range. These results were supportive of the paraneoplastic syndrome of SIADH secondary to SmCCa. DMSA scan showed a 19% split function in the right kidney. Percutaneous nephrostomy was not inserted as per the patient’s preference. Six cycles of neoadjuvant chemotherapy (NACT)—Carboplatin and half dose of Etoposide were given due to reduced renal function (eGFR: 36 ml/min). Sodium levels improved and remained improved to normal range with NACT (Fig. 4).
Re-staging CT CAP after NACT showed an almost complete resolution of bladder and ureteric lesion (Fig. 5). Radical surgery and radiotherapy were discussed for definitive management via a multidisciplinary approach. The patient opted for radical radiotherapy and accepted no further invasive intervention. The patient completed consolidation radiotherapy (40 Gy in 15 fractions) to the bladder and lower ureter. Surveillance CT CAP and further surveillance showed no evidence of disease progression, at last, follow-up of 20 months.
SmCCa is highly aggressive cancer and also known as undifferentiated carcinoma, small cell anaplastic carcinoma, neuroendocrine small cell carcinoma and oat cell carcinoma. The most common site is lung however it can be found in any organ. GU SmCCa is uncommon. The most common site of SmCCa is the bladder (58.8%) and prostate (33.3%) . Upper tract SmCCa is very rare (renal 4.4% and ureter 3.3%). The pathophysiology of GU SmCCa is unclear. It is possibly derived from the urothelium with neuroendocrine differentiation or from neuroendocrine cells that are already present in the urinary tract. An alternative hypothesis is that these cells originated from a multipotential stem cell with the potential to differentiate into various tissue types (transitional cell, squamous cell, neuroendocrine cell, etc.) .
It is most commonly found in the seventh decade, with a male to female ratio of up to 5:1 [1, 2]. Visible haematuria is the most common presentation and diagnosis is usually made on histopathological examination [3, 5]. Outcomes of GU SmCCa remain poor as it typically presents with locally advanced or disseminated disease. In a review, metastases were found in 40% of patients with median overall survival (OS) of 10.5 months . Our patient was found to have a ureteric tumor which rapidly progressed to involve the bladder within 6 weeks from the diagnosis, suggesting an extremely aggressive tumor kinetic.
For primary SmCCa of the bladder, OS is 18 to 20.7 months with 3 years and 5 years OS 37.5% and 28.2%, respectively . Age, gender, marital status, the ratio of the positive lymph nodes, size of the tumor, T stage, NACT and downstaging, have all been shown to be significantly associated with OS [2, 6]. The OS of SmCCa of the bladder treated with radiotherapy (RT) ranges between 20% and 70% while survival of 25% to 78% is reported with radical cystectomy (RC) [7,8,9,10]. NACT with Cisplatin-based chemotherapy showed better survival to (CSS 78%) patients who had RC only (CSS 36%) . It is hard to compare long-term outcomes between NACT + RT and NACT + RC due to the lack of randomized controlled studies, however, both are associated with increased OS compared to monotherapy [10,11,12].
Due to the rarity of upper tract SmCCa, management guidance is only available from case reports. Majhail et al. reported a median OS of 8 months in 22 renal SmCCa. OS after RN and RN with chemotherapy was 5 months and 8.5 months, respectively . Progression-free survival of 24 months to 38 months was reported when patients received platinum-based NACT before radical surgery. It seemed that multimodal treatment with platinum-based NACT followed by surgery provided a better outcome. A summary of ureteric SmCCa case reports is presented in Table 1.
Tumor related hyponatraemia is very with GU SmCCa and only six case reports in the literature described SIADH related hyponatremia associated with GU SmCCa [3, 5]. Five out of six studies showed association with prostate SmCCa. It was seen that SIADH associated with GU SmCCa resolved with chemo-radiotherapy or radical resection [3, 5]. In our case patient had normal sodium levels prior to the presentation with haematuria and hyponatremia was noted at presentation which became more severe after TURBT. Further investigations concluded that this was due to SIADH secondary to SmCCa. In our patient, sodium levels became normal after treatment with NACT and RT.
This case has provided sequential management outcomes since presentation to the last surveillance follow up for at least 20 months duration with good outcome. As this is rare to have SmCCa of ureter and even more rare to have associated SIADH with such tumor, it will add better understanding in management of these cancers. The case study is limited by retrospective data collection.
In summary, haematuria and hyponatremia were our patient’s first clinical manifestations, leading to the discovery of SmCCa of the ureter. To our knowledge, this case represents the only documented case of paraneoplastic SIADH attributable to ureteric SmCCa with progression to the bladder.
The presence of hyponatraemia and GU lesion should raise the suspicion of paraneoplastic SIADH secondary to SmCCa. Biopsy of GU lesion with such presentation could help in the decision of NACT before definitive surgical management. This case also demonstrated the effectiveness of NACT and RT in the management of ureteric SmCCa.
Availability of data and materials
Cancer Specific Survival
- CT CAP:
CT Chest, Abdomen and Pelvis
Contrast Enhanced CT
Small Cell Carcinoma
Syndrome of Inappropriate Anti-Diuretic Hormone
Trans Urethral Resection of Bladder Tumor
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Chuang, YH., Nandwani, G.M., Szewczyk-Bieda, M. et al. Primary small cell carcinoma of the ureter with associated hyponatremia and rapid progression to bladder involvement: a case report. Afr J Urol 28, 24 (2022). https://doi.org/10.1186/s12301-022-00291-w
- Small cell carcinoma