Fig. 2

A medium power view of the lesion (A) showing features of a high-grade malignant tumor that is muscle invasive. The tumor shows no overt evidence of urothelial differentiation, but the morphological features do suggest a neuroendocrine phenotype. A higher power view (B) demonstrates prominent proliferation with numerous mitotic figures, some atypical, together with evidence of apoptosis. The tumor shows widespread positive staining for synaptophysin (C)