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Multitract percutaneous nephrolithotomy in the management of staghorn stones

Abstract

Background

Staghorn stones are difficult to manage with a risk of significant renal impairment and urosepsis. Percutaneous nephrolithotomy is the first-line treatment for staghorn stones. Often, multiple access tracts are needed to render the patient stone-free. PCNL has been combined with SWL, flexible URS (ECIRS), and mini-PCNL to access residual fragments without the need of additional tracts. However, in a country with limited access to technology and a restraint on resources, multitract PCNL still is the preferred option. The aim of this study was to assess the safety and efficacy of multitract PCNL in such an environment.

Methods

We analyzed data on sixty-five patients with staghorn calculus who underwent multitract PCNL for a staghorn calculus. Data included demographics, stone parameters, intraoperative parameters, complications and clinical outcomes. Hb-drop and creatinine changes were assessed pre- and post-OP. Complications were graded according to the modified Clavien-Dindo classification.

Results

In a total of 65 patients [47 males (72%)], 154 percutaneous access tracts were used in 66 renal units. The number of tracts varied between 2 and 4 in a single renal unit. The stone-free rate was 85%. 20% of patients developed grade I, 14% grade II, and 3% grade III b complications. There were no grade IV and V complications.

Conclusion

Multitract PCNL is safe and efficient, with a good stone-free rate and an acceptable complication rate. When auxiliary combination treatments are not available, multitract standard PCNL remains an option.

Background

The treatment of staghorn stones is challenging. Due to their high recurrence rates, particularly in infectious stones, complete removal of stone material is mandatory [1].

The estimated five-year recurrence rate is up to 50% [2]. Staghorn stones, by definition, are branched into two or more calyces. Particularly when the stone burden reaches > 2000 mm2, surgical treatment remains technically difficult regardless of the treatment modality used [3].

Different treatment modalities include open surgery, laparoscopy, percutaneous nephrolithotomy (PCNL), multi-staged ureterorenoscopy (URS) in selected cases, and endoscopic combined intrarenal surgery (ECIRS). Some studies suggested that open or laparoscopic surgery is an efficient method for the management of large and complex renal stones associated with a high single-session stone-free rate [4, 5]. Notwithstanding the fact that both are more invasive, PCNL can easily be repeated if needed, whereas laparoscopic or open surgery become more complicated after an initial procedure due to anatomical changes and scarring [6].

PCNL is regarded as the treatment of choice for staghorn calculi [7]. Although it has stood the test of time as a minimally invasive, safe, and efficient procedure in its various forms, it is associated with an overall complication rate of 25%, usually assessed with the modified Clavien-Dindo classification [8]. The most frequent complications are fever (0–32%) and bleeding requiring blood transfusion (0–20%) [9]. Radiation exposure during PCNL is another concern still discussed [10]. Over time, the safety and efficacy of PCNL have improved through various changes and modifications [11]. The introduction of flexible URS and its combination with PCNL (ECIRS) has aided in the most complex cases and, in many instances, abolished the need for multiple punctures [12]. Flexible ureterorenoscopy is however not widely available in the developing world. These scopes are expensive, fragile, of limited lifetime, and require a specific back-up infrastructure (light and camera system, sterilization, disposables, etc.).

Many complex staghorn stones, therefore, do require multiple accesses into various calyces in order to access and remove all parts of the stone [13]. The debate continues whether to do a single tract procedure with a 2nd look PCNL, or sandwich therapy in which initial PCNL is combined with extracorporeal shock wave lithotripsy (SWL) and followed by another 2nd look PCNL, or rather a multitract PCNL in an attempt to render the patient stone-free in one single session. The latter may achieve a stone-free rate of 84–95% [14]. Moreover, multitract single-session PCNL would bring down costs significantly by avoiding multiple procedures of any kind [15,16,17]. Multitract PCNL has a similar complication rate compared to combined treatments [18], although some studies suggest multiple tracts as a cause for peri-operative bleeding [19, 20].

Most data on multitract PCNL come from well-established stone centers in the developed world [1, 2, 7, 9,10,11,12, 14, 16, 17]. As a developing country, we do not have easy access to multi-modality treatments because they are not available or affordable to the patients, and hence we have to use resources sparingly. Therefore, multitract PCNL remains our treatment of choice in patients with large complex stone burdens. In this study, we assessed whether multitract PCNL is efficient and safe in our hands in terms of stone-free rate and complication-rate. We believe that these data are important for stake-holders in similar economic environments.

Methods

Ethical approval was obtained from the National Board for Medical Specializations (Urology).

Sixty-five patients who underwent elective PCNL for large and complex staghorn stones between August 2016 and April 2019 were included and prospectively analyzed.

The preoperative workup included complete medical history, physical examination, and laboratory investigations (urinalysis, complete blood count, blood biochemistry, coagulation profile, renal function test, viral markers, and blood group with cross-match). Preoperative imaging included ultrasound-KUB and an unenhanced CT scan in all patients.

Patients with uncontrolled coagulopathy, severe musculoskeletal deformities, pregnancy, and active infections were excluded.

Preoperative data recorded were age, gender, BMI, comorbidities, previous surgeries, site and size of the stone, and the presence of hydronephrosis.

Intraoperative data included the type of anesthesia, number of tracts, tract diameters, point of entry to the collecting system, intraoperative bleeding, extravasation, pelvic and PUJ injury, and operative time.

Postoperatively, blood transfusion, fever, sepsis, thoracic complications, transient hematuria, transient renal function disorder, and stone-free rate were recorded.

All patients were operated by the same highly experienced surgeon in a high-volume stone center with a standard prone PCNL in either spinal or general anesthesia, under prophylactic IV-administration of a third-generation cephalosporin at induction. Access was obtained with fluoroscopy guidance and serial plastic dilators. A F18 standard rigid nephroscope (Karl Storz, Tuttlingen, Germany) and pneumatic lithotripsy were used (NidhiLith, Nidhi Medical systems, Delhi, India). When it was not possible to reach all stones, additional PCNL tracts were laid. The procedure was continued until stone-freeness was confirmed radiologically and optically, or safe continuation had become compromised by impaired vision, mostly through bleeding. All patients had an anterograde JJ stent, a percutaneous nephrostomy (PCN), and a bladder catheter. The latter was removed after 6 h, the PCN after 24 h unless there was persistent bleeding.

Hb was measured after 24 h again, postoperatively. Under the assumption that one transfused unit of blood increases the Hb by 1 gr/dL, Hb-drop was calculated as:

$${\text{Hb - drop}} = \left( {{\text{Preoperative}}\;{\text{Hb}} - {\text{postoperative}}\;{\text{Hb}}} \right) + \left( {{\text{number}}\;{\text{of}}\;{\text{units}}\;{\text{transfused}} \times 1\,{\text{g}}/{\text{dL}}\;{\text{Hb}}\;{\text{per}}\;{\text{unit}}\;{\text{transfused}}} \right)\;\left[ {21} \right]$$

Complications were graded according to the modified Clavien-Dindo system.

Patients were assessed for residual fragments by Xray and US KUB 2 weeks postoperatively. Patients were kept on ongoing regular follow-ups and late complications were recorded.

Data were analyzed using the Statistical Package for Social Sciences (SPSS version 25). A paired T test was used for comparative analyses. A p value < 0.05 was considered statistically significant.

Results

Data on 65 patients were analyzed in this study, thereof 47 (72%) males. Mean age was 43.2 ± 13.7 years (20–70 years). Mean BMI was 26.4 ± 4.5. As the most prevalent comorbidities, diabetes mellitus was present in 12 (18%), high blood pressure in 15 (23%), and a combination of both in 5 (8%).

The mean stone burden was 60 ± 18 mm (36–120 mm). Mild/moderate/severe hydronephrosis was present in 45/26/15% of cases, respectively. Half of the stones were in the right kidney. Fifty-seven (88%) of patients had had previous stone interventions (Table 1).

Table 1 Patients (n = 65) and stones

Mean OP time was 79 ± 25 min (55–160 min). The vast majority of patients were operated upon under spinal anesthesia.

The number of tracts needed to achieve stone clearance varied from 2 to 4 in a single renal unit. A total of 154 percutaneous access tracts were established in 66 renal units, thereof 33 (50%) on the right side. Two tracts were used in 48 (72%), three in 14 (22%), and four in 4 (6%), respectively. Tracts were positioned in 66 (43%) in the lower pole, in 52 (34%) in the middle pole, and in 36 (23%) in the upper pole of the kidneys.

As to laboratory parameters, the mean creatinine did not significantly change from preoperative levels at 24 h post-PCNL. In contrast, the Hb level did drop from 13.8 ± 1.3 gr/dL (9.1–16.3) to 11.1 ± 1.1 gr/dL (7.8–14.2). This was statistically significant with a mean Hb-drop of 2.7 gr/dL. Six (9%) patients required blood transfusion. The mean hospital stay was 1.5 days (Table 2).

Table 2 Operation and immediate postoperative outcomes

Clavien grade I complications occurred in 13 (20%) cases: fever in 7 (11%), transient impairment of renal function in 2 (3%), nausea/vomiting in 4 (6%).

Clavien grade II complications occurred in 9 (14%) cases: blood transfusion in 6 (9%), infection requiring additional antibiotics in 2 (3%), transient urinary leakage in 1 (1.5%).

Calvien grade IIIb complications occurred in 2 (3%) cases: bleeding and abortion of PCNL in 1 (1.5%), postoperative renal colic after JJ removal and URS in 1 (1.5%). There were no Clavien IV and V complications (Table 3). We observed no late complications after more than 2 weeks post-PCNL.

Table 3 Complications according to the Calvien grading system

84.8% of patients were completely stone-free after one session of multitract PCNL. Of the 10 patients with residual fragments, 2 (3%) underwent a 2nd look PCNL, 1 (1.5%) URS, 5 (7%) opted for conservative management, and 2 (3%) refused further treatment (Table 4).

Table 4 Follow-up and adjuvant treatments

Discussion

The target of surgical intervention in staghorn stones is to achieve complete stone clearance to prevent recurrences and associated complications [22].

To increase the stone-free rate, many investigators evaluated multitract PCNL, either with standard PCNL or mini-PCNL, or a combination of both. The term “mini-PCNL” has been described by Manohar et al. [19]. With reduced-size instruments, they obtained complete stone clearance in 86% of cases, albeit with more than 60% of cases needing multiple tracts.

Cho et al. [23] found that in appropriately chosen patients, a multitract PCNL is safe and efficient. Fei et al. [24] achieved a 78% stone-free rate in 55 patients with complete staghorn stones who underwent multitract PCNL. They found multitract PCNL crucial to increase total stone clearance and to reduce reliance on supplemental extracorporeal lithotripsy and/or 2nd look PCNL. However, they used a flexible nephroscope to retrieve small peripheral fragments and to confirm stone clearance on the one hand, and to establish the need and location for another puncture on the other hand.

In our study, we achieved an 85% stone-free rate, which is comparable with other studies (84–89%) [24,25,26].

It is noteworthy that the hospital stay was only 1.5 days on average. This is because most of our patients (72%) needed only two tracts, which were removed usually after 24 h. Patients then were observed for a few hours and discharged on antibiotics.

One shortcoming of our study is that we relied on US and Xray alone to establish stone-free status, which may overestimate stone-free status by 17–35% [27]. Admittedly, using a CT scan post-procedure to detect residual fragments would be the more accurate method. But again, this is a report from a developing country with limited and restrained resources, and we make use of what we have easily and cost-effectively available.

The rate of blood transfusion in our study was 9.2%, which compares favorably with the literature (7.7–45%) [21, 22, 28, 29].

The overall complication rate using the modified Clavien–Dindo classification of surgical complications was 36.8%, which corresponds again with other authors’ findings (30–41%) [25, 26]. Most complications were grade I and II. None of our cases developed bleeding that required super-selective angioembolization. Despite controversies in the literature concerning the impact of BMI on the outcome of PCNL, Chen et al. [30] found that BMI has neither affected the stone-free rate nor the postoperative complication rate in patients undergoing PCNL. The same findings were observed in our patients.

Limitations to our study are the relatively small number of cases and—as mentioned above—the use of Xray and US KUB, which have the potential to overestimate the stone-free rate. Also, procedures were performed by a highly experienced high-volume stone surgeon. Rates achieved might therefore not be fully representative for general urologists.

Conclusion

Multitract PCNL is feasible, safe, and efficient in managing staghorn calculi, with acceptable morbidity and complications. When auxiliary combination treatments are not available, multitract standard PCNL remains a good option.

Availability of data and materials

Not applicable.

Abbreviations

BMI:

Body mass index

CT:

Computertomography

dL:

Deciliter

ECIRS:

Endoscopic combined intrarenal surgery

F:

French

gr:

Gram

Hb:

Hemoglobin

JJ:

Double-J

KUB:

Kidney, ureter, bladder

mm:

Millimeter

OP:

Operative

PCN:

Percutaneous nephrostomy

PCNL:

Percutaneous nephrolitholapaxy

SWL:

Extracorporeal shock wave lithotripsy

URS:

Ureterorenoscopy

US:

Ultrasound

y:

Year

References

  1. 1.

    Pastore AL, Palleschi G, Silvestri L, Leto A, Ripoli A, Fuschi A, Al Salhi Y, Autieri D, Petrozza V, Carbone A (2016) Combined laparoscopic pyelolithotomy and endoscopic pyelolithotripsy for staghorn calculi: long-term follow-up results from a case series. Therap Adv Urol 8(1):3–8

    Article  Google Scholar 

  2. 2.

    Fink HA, Wilt TJ, Eidman KE et al (2013) Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline. Ann Int Med 158(7):535–543

    Article  Google Scholar 

  3. 3.

    Singla M, Srivastava A, Kapoor R, Gupta N, Ansari MS et al (2008) Aggressive approach to staghorn calculi safety and efficacy of multiple tracts percutaneous nephrolithotomy. Urology 71:1039–1042

    Article  Google Scholar 

  4. 4.

    Basiri A, Tabibi A, Nouralizadeh A et al (2014) Comparison of safety and efficacy of laparoscopic pyelolithotomy versus percutaneous nephrolithotomy in patients with renal pelvic stones: a randomized clinical trial. J Urol 11(6):1932–1937

    Google Scholar 

  5. 5.

    Haggag YM, Morsy G, Badr MM et al (2013) Comparative study of laparoscopic pyelolithotomy versus percutaneous nephrolithotomy in the management of large renal pelvic stones. Can Urol Assoc J 7(3–4):E171–175

    Article  Google Scholar 

  6. 6.

    Liang T, Zhao C, Wu G, Tang B, Luo X, Lu S, Dong Y, Yang H (2017) Multi-tract percutaneous nephrolithotomy combined with EMS lithotripsy for bilateral complex renal stones: our experience. BMC Urol 17(1):15

    Article  Google Scholar 

  7. 7.

    Handa RK, Evan AP, Willis LR, Johnson CD, Connors BA, Gao S, Lingeman JE, Matlaga BR, Miller NL, Handa SE (2009) Renal functional effects of multiple-tract percutaneous access. J Endourol 23(12):1951–1956

    Article  Google Scholar 

  8. 8.

    Mandal S, Goel A, Kathpalia R et al (2012) Prospective evaluation of complications using the modified Clavien grading system, and of success rates of percutaneous nephrolithotomy using Guy’s Stone Score: a single-center experience. Indian J Urol 28:392–398

    Article  Google Scholar 

  9. 9.

    Türk C, Petřík A, Sarica K, Seitz C, Skolarikos A, Straub M, Knoll T (2016) EAU guidelines on interventional treatment for urolithiasis. Eur Urol 69(3):475–482

    Article  Google Scholar 

  10. 10.

    St-Laurent MP, Doizi S, Rosec M, Terrasa JB, Villa L, Traxer O, Cloutier J (2019) Radiation exposure in prone vs. modified supine position during PCNL: results with an anthropomorphic model. Can Urol Ass J 13(8):246

    Google Scholar 

  11. 11.

    Sesmero JA, Delgado MC, de la Cruz Martín B, Rodriguez JM, Fernández DA, Tesedo VR, Way DM, Aceves JG (2017) Small-caliber percutaneous nephrolithotomy (SC-PCNL). Therapeutic decision algorithm. Actas Urológicas Españolas (English Edition) 41(9):552–561

    Google Scholar 

  12. 12.

    Otas D, Milenkovic PD, Predrag N, Djordje A, Bojan C, Uros B, Milan R, Aleksandar J, Skolarikos A (2018) Multi-tract percutaneous nephrolithotomy approach. Hellenic Urol 12:30

    Google Scholar 

  13. 13.

    Elawady H, Mostafa DE, Mahmoud MA, Abuelnaga M, Farouk A, Tawfick A, Elzayat T, Ahmed A (2018) Is multiple tracts percutaneous nephrolithotomy (PCNL) safe modality in the management of complex renal stones? A prospective study: a single-center experience. Afr J Urol 24(4):308–314

    Article  Google Scholar 

  14. 14.

    Tan MAV, Lusaya DG (2019) Multiple vs. single access PCNL. In Endourol Progress, pp 57–63

  15. 15.

    Li JK, Teoh JY, Ng CF (2019) Updates in the endourological management of urolithiasis. Int J Urol 26(2):172–183

    Article  Google Scholar 

  16. 16.

    Aron M, Yadav R, Goel R et al (2005) Multi-tract percutaneous nephrolithotomy for large complete staghorn calculi. Urol Int 75:327–332

    Article  Google Scholar 

  17. 17.

    Hegarty NJ, Desai MM (2006) Percutaneous nephrolithotomy requiring multiple tracts: comparison of morbidity with single-tract procedures. J Endourol 20:753–760

    Article  Google Scholar 

  18. 18.

    Zhong W, Zeng G, Wu W, Chen W, Wu K (2011) Minimally invasive percutaneous nephrolithotomy with multiple mini tracts in a single session in treating staghorn calculi. Urol Res 39:117–122

    Article  Google Scholar 

  19. 19.

    Manohar T, Ganpule AP, Shrivastav P, Desai M (2006) Percutaneous nephrolithotomy for complex caliceal calculi and staghorn stones in children less than five years of age. J Endourol 20:547–551

    CAS  Article  Google Scholar 

  20. 20.

    Netto NR Jr, Ikonomidis J, Ikari O, Claro JA (2005) Comparative study of percutaneous access for staghorn calculi. Urology 65:659–662

    Article  Google Scholar 

  21. 21.

    Said SH, Hassan MA, Ali RH, Aghaways I, Kakamad FH, Mohammad KQ (2017) Percutaneous nephrolithotomy; alarming variables for postoperative bleeding. Arab J Urol 15(1):24–29

    Article  Google Scholar 

  22. 22.

    Chen J, Zhou X, Chen Z, Liu L, Jiang L, Chen C, Qi L, Zu X, Chen H (2014) Multiple tracts percutaneous nephrolithotomy assisted by LithoClast master in one session for staghorn calculi: report of 117 cases. Urolithiasis 42(2):165–169

    CAS  Article  Google Scholar 

  23. 23.

    Cho HJ, Lee JY, Kim SW, Hwang TK, Hong SH (2012) Percutaneous nephrolithotomy for complex renal calculi: Is multi-tract approach OK? Can J Urol 19:6360–6365

    PubMed  Google Scholar 

  24. 24.

    Fei X, Li J, Song Y, Wu B (2014) Single-stage multiple-tract percutaneous nephrolithotomy in the treatment of staghorn stones under total ultrasonography guidance. Urol Int 93(4):411–416

    CAS  Article  Google Scholar 

  25. 25.

    Zhao Z, Cui Z, Zeng T, Wan SP, Zeng G (2016) Comparison of 1-stage with 2-stage multiple-tracts mini-percutaneous nephrolithotomy for the treatment of staghorn stones: a matched cohorts analysis. Urology 1(87):46–51

    Article  Google Scholar 

  26. 26.

    Wang Y, Hou Y, Jiang F, Wang Y, Chen Q, Lu Z, Hu J, Wang X, Lu J, Wang C (2014) Standard tract combined with mini-tract in percutaneous nephrolithotomy for renal staghorn calculi. Urol Int 92(4):422–426

    Article  Google Scholar 

  27. 27.

    Ganpule A, Desai M (2009) Fate of residual stones after percutaneous nephrolithotomy: a critical analysis. J Endourol 23(3):399–403

    Article  Google Scholar 

  28. 28.

    Liatsikos EN, Kapoor R, Lee B, Jabbour M, Barbalias G, Smith AD (2005) ‘Angular percutaneous renal access’. Multiple tracts through a single incision for staghorn calculous treatment in a single session. Eur Urol 48:832–837

    Article  Google Scholar 

  29. 29.

    Kukreja R, Desai M, Patel S, Bapat S, Desai M (2004) Factors affecting blood loss during percutaneous nephrolithotomy: a prospective study. J Endourol 18:715–722

    Article  Google Scholar 

  30. 30.

    Chen Tsai-Feng, Chen Chung-Hsin, Lee Yuan-Ju (2018) The role of body mass index predicting the outcome of percutaneous nephrolithotomy. Urol Sci 29(5):252

    Google Scholar 

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Authors

Contributions

SNM recorded, collected and assisted analyzing the data. AKA recorded, collected and assisted analyzing the data. OAR recorded, collected and assisted analyzing the data and was instrumental in developing the concept of the study. RB developed the concept, initialized the study, and wrote the first draft paper. NB reviewed, edited and submitted the final version. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Noor Buchholz.

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Ethics approval and consent to participate

Ethical approval was obtained from the Iraqi Board for Medical Specialization and consent to participate (Urology) approval number 4691. All participants gave written consent prior to their operation to be included in the study.

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Competing interests

None declared by any of the authors.

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U-merge Ltd. (Urology for Emerging Countries) is an academic urological platform dedicated to facilitate knowledge transfer in urology on all levels from developed to emerging countries. U-merge Ltd. is registered with the Companies House in London/UK. www.U-merge.com

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Rashid, A.O., Mahmood, S.N., Amin, A.K. et al. Multitract percutaneous nephrolithotomy in the management of staghorn stones. Afr J Urol 26, 74 (2020). https://doi.org/10.1186/s12301-020-00086-x

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Keywords

  • Percutaneous nephrolithotomy
  • Staghorn stones
  • Multiple tracts
  • Complications
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