Table 2 Distribution of V89L and G34R polymorphisms among hypospadias cases and controls
Cases (n = 50) | Control® (n = 50) | χ2 (MCp) | p0 | OR (LL–UL 95% CI) | p0 | AOR (LL–UL 95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|
No | % | No | % | ||||||
V89L | |||||||||
VV® | 22 | 44.0 | 50 | 100.0 | 44.617* (< 0.001*) | ||||
VL | 25 | 50.0 | 0 | 0.0 | – | – | – | – | |
LL | 3 | 6.0 | 0 | 0.0 | – | – | – | – | |
HWE | 0.233 | – | |||||||
Allele | (n = 100) | (n = 100) | |||||||
V® | 69 | 69.0 | 100 | 100.0 | 36.686* (< 0.001*) | ||||
L | 31 | 31.0 | 0 | 0.0 | – | – | – | – | |
G34R | |||||||||
GG® | 29 | 58.0 | 40 | 80.0 | 5.972* (< 0.031*) | 0.027* | 2.759 (1.125–6.765) | 0.153 | 2.283 (0.724–7.850) |
GR | 20 | 40.0 | 10 | 20.0 | |||||
RR | 1 | 2.0 | 0 | 0.0 | – | – | – | – | |
HWE | 0.242 | 0.432 | |||||||
GR + RR | 21 | 42.0 | 10 | 20.0 | 5.657* (0.017*) | 0.019* | 2.897 (1.187–7.067) | 0.131 | 2.490 (0.762–8.140) |
Allele | (n = 100) | (n = 100) | |||||||
G® | 78 | 78.0 | 90 | 90.0 | 5.357* (0.021*) | 0.024* | 2.539 (1.133–5.687) | 0.144 | 2.193 (0.765–6.287) |
R | 22 | 22.0 | 10 | 10.0 | |||||