2.1 Case 1
A 40-year-old male non-smoker presented with a four months history of right flank pain without fever and hematuria. He underwent right open pyelolithotomy 10 years back. Abdominal examination revealed right renal angle tenderness. Routine hematological investigations were normal. There was no red or pus cell on urine analysis. Serum creatinine was 0.7 mg/dL.
Abdominal sonography showed gross right hydronephrosis. Multiphasic contrast-enhanced abdominal tomography (CECT) revealed grossly hydronephrotic right kidney with papery thin parenchyma and few small calculi in lower and middle calyx. Right ureter was not dilated (Fig. 1a). DTPA renal scanning revealed 5% split function of the right kidney.
A percutaneous nephrostomy (PCN) was placed that drained a small quantity of gelatinous material which did not show malignant changes on cytopathological examination. The patient underwent laparoscopic simple nephrectomy without total ureterectomy with intraoperative spillage of mucinous content.
Gross pathological examination of the kidney showed gelatinous polypoidal material in calyces and pelvis (Fig. 1b). Microscopic examination shows the renal pelvis was composed of atypical columnar epithelial cells with multiple acini and few papillary fronds suggestive of adenocarcinoma (Fig. 1c). Whole-body positron emission tomography-CT (PET-CT) ruled out any other site for adenocarcinoma.
Adjuvant chemotherapy was offered to the patient considering the intraoperative spillage, but the patient refused. Patient was asymptomatic with normal CECT Chest and abdomen-pelvis for a recorded follow-up period of 12 months.
2.2 Case 2
A 60-year-old male underwent right open pyelolithotomy 2 years prior for renal calculi. After six months he was diagnosed with an obstructive right mid-ureteric calculus and underwent right PCN insertion followed by right ureteroscopic lithotripsy at peripheral center. After 3 months, he presented to us with right side flank pain and intermittent discharge from the previous nephrostomy site. He was afebrile with no history of hematuria. Hematological investigation showed elevated total leucocyte count of 18,500 cells/mm3 [Normal range: 4,000–11,000 cells/mm3] and serum creatinine 1.2 mg/dl. Urinalysis showed 60–70 pus-cells/hpf. CECT showed grossly hydronephrotic right kidney and a loculated perinephric hypodense collection with peripheral enhancement communicating the pelvicalyceal system (PCS). The right renal cortex was papery thin and no contrast excretion was seen on delayed scan (Fig. 2a). Considering a right renal abscess as the working diagnosis, a right PCN was inserted. Thick pus along with mucoid material was drained. Preoperative working diagnosis of a pyonephrotic non-functional kidney was made, and the patient underwent open right nephrectomy. Intraoperatively dense perinephric adhesions were present with spillage of mucoid material at some places. Gross pathological examination showed grossly dilated PCS filled with gelatinous material and multiple brownish papillary nodules seen on the surface of renal pelvis and calyces (Fig. 2b). Histopathological examination showed neoplastic glands lined by pseudostratified columnar epithelium with vacuolated cytoplasm suggestive of well-differentiated adenocarcinoma (Fig. 2c). Final pathological stage pT3aNx in light of opened PCN tract. PET-CT ruled out any other site of origin of disease. The patient was disease-free by the 18-month postoperative follow-up.
2.3 Case 3
A 57-year-old male non-smoker presented with three episodes of painless hematuria along with intermittent pain in the left flank. He was afebrile with unremarkable past history. His routine hematological and urine investigations were normal.
CT urography showed thickened enhancing mid-ureteric wall with luminal narrowing involving the short segment of left ureter. Non-excretion of contrast in the pelvicalyceal system was reported even on 15 min delayed scan (Fig. 3a). Rest all organs were normal. Urine cytology was negative.
Cystoscopic evaluation of bladder was unremarkable and ureteroscopic showed intraluminal protruding irregular mass in left mid ureter. Ureteroscopic-aided biopsy of left ureteric mass reported villous adenoma (Fig. 3b). DTPA renal scan revealed poorly functioning left kidney with GFR of 14 ml/min. The contralateral kidney was normal. The patient underwent laparoscopic left nephroureterectomy with bladder cuff excision. Intraoperatively, the ureter was clipped distal to mass and tissue sent for frozen section showed presence of tumor. Subsequently, entire ureter along with bladder cuff excision was done.
Histopathological examination reported 1 × 0.5 cm well-differentiated adenocarcinoma in ureteric segment which invades beyond muscularis into periureteric fat (Fig. 3c). In view of piecemeal resection of distal ureteric segment, chemotherapy was advised to patient but he denied. Patient succumbed to death 32 months after surgical intervention.