Giant prostatic hyperplasia: case presentation of the second largest prostate adenoma
African Journal of Urology volume 27, Article number: 27 (2021)
Benign prostate hyperplasia is one of the most common diseases in middle-aged or older men. Approximately 50% of men over 60 years old suffer from benign prostatic hyperplasia. Giant prostatic hyperplasia is defined as a prostate exceeding 500 g. In all the literature, ten case reports were published with giant prostatic hyperplasia.
In this case report, we present a 72-year-old man with edema of lower extremities. In physical examination, bilateral pitting edema of the lower extremities was detected. Serum prostate-specific antigen level was > 100.00 ng/ml. He did not have lower urinary tract symptoms. International Prostate Symptom Score (IPSS) and uroflowmetry results proved that the patient did not have lower urinary tract symptoms. Radiologic imaging revealed a huge pelvic mass behind bladder. Grade 1 hydronephrosis in the right kidney was detected, but serum creatinine value was normal. This mass was excised with open surgery. This mass was measured 1090 g, and histopathologic examination showed benign prostatic hyperplasia. The patient had no complication at the 12-month follow-up. After 5 years, prostate volume was calculated approximately 108 cc by computer tomography but still the patient did not have any lower urinary tract symptoms.
It is important to approach the retroperitoneal mass. Clinicians usually think about malignity, but sometimes that mass can be relevant with benign process. Intra-operative biopsy can help clinicians for both diagnosis and surgical approach. In this case presentation, we report a patient with one of the largest sizes of prostate gland that measured 1090 g.
Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-aged or elderly men . This disease can usually cause lower urinary tract symptoms, renal failure or pelvic symptoms such as pain. BPH is determined by digital rectal examination, uroflowmetry and radiographic imaging. Rarely, prostate can reach huge size and be seen as an intra-abdominal mass. Giant prostatic hyperplasia is defined as a prostate exceeding 500 g . Unlike classical benign prostatic hyperplasia symptoms, these types of giant prostatic hyperplasia may be recognized clinically by compression symptoms such as edema in the extremities, decreased peripheral arterial pulse and/or loss of sensation on the skin. Although it can be seen as a retroperitoneal mass in the first evaluation, it may surprise with the results of intra-operative findings and histopathologic examination. In this case, we report a 72-years-old patient admitted to clinic for edema of the lower extremities without lower urinary tract symptoms. After operation, a giant prostatic hyperplasia was detected on histopathologic examination with 1090 g.
2 Case presentation
A 72-year-old male was presented with edema of lower extremities. Patient had no lower urinary tract symptoms such as nocturia, dysuria or intermittency. There was no chronic disease or medical drug use in the medical history except total thyroidectomy. On physical examination, there was a palpable mass on umbilical area. On rectal examination, a grade 2, rigid prostate without a nodule was palpated. Serum biochemistry and urine analysis were normal, but serum prostate-specific antigen level was > 100.00 ng/ml. In uroflowmetry, Qmax value was 15 ml/s and total bladder capacity was 310 ml. Post-micturition residual volume was 40 ml. Urinary USG revealed a pelvic solid mass behind bladder. Computer tomography enhanced a solid mass measured 15 × 12 cm (Fig. 1). Bilateral kidney contour was normal, and grade 1 hydronephrosis in the right kidney was detected. International Prostate Symptom Score (IPSS) of patient was 6. Transrectal ultrasonographic biopsy was performed, and histopathologic examination revealed atypical small acinar proliferation.
On urethrocystoscopy, bladder outlet was semi-obstructed but prostatic urethra was not obstructed with prostate lobes. After urethrocystoscopy, a midline incision was performed and the peritoneum was medialized to reach the retroperitoneal space. The mass of approximately 15 cm that pushed bladder anteriorly was excised. The mass was found to be related to the prostatic lodge, but the prostatic lodge could not be completely excised due to increased hemorrhage. The patient was hospitalized 6 days with no complication. Histopathologic examination revealed benign prostatic hyperplasia (Fig. 2). Serum PSA level was 1.9 ng/ml 6 months after surgery. After 5 years, prostate volume was calculated approximately 108 cc on computer tomography (Fig. 3), but still the patient did not have any lower urinary tract symptoms and IPSS was still 6. Informed consent was obtained from the patient.
When PSA level is very high and irritative symptoms are less, clinicians’ first diagnosis can be prostate cancer. Transrectal ultrasonography-guided prostate biopsy results may not be proportional to PSA level. The term giant prostatic hyperplasia is defined as a prostate exceeding 500 g . Medina-Peres et al. report cases with a size of 2410 g  and Tolley DA et al. 1058 g in size  (Table 1).
Clinical diagnosis of solitary subcervical or median lobe hypertrophy can be quite difficult . In some cases, nor digital rectal examination neither radiologic imaging can help to detect median lobe as it grows intravesically. If median lobe grows intravesically, irritative symptoms can be less. Patients may not have any lower urinary tract symptoms, and IPSS result may be misleading.
In our case, an intra-abdominal mass was detected incidentally in a patient who was investigated for edema in the bilateral lower extremities. He did not have lower urinary tract symptoms. International Prostate Symptom Score (IPSS) and uroflowmetry result proved that the patient did not have lower urinary tract symptoms. Serum creatinine level was normal. Radiologic imaging showed us that mass’ diameter was approximately 15 cm. With the PSA level, we thought that the retroperitoneal mass accompanied by prostate cancer but transrectal ultrasonography-guided prostate biopsy result did not confirm our decision.
To our knowledge, our case is the second heaviest prostate adenoma resected by surgery. Also Dominguez et al. report the highest prostate volume with 3987 ml. However, the patient did not need surgery .
It is important to approach the retroperitoneal mass. Clinicians usually think about malignity, but sometimes that mass can be relevant with benign process. Intra-operative biopsy can help for diagnosis, and clinicians can change their surgical approach to pelvis masses.
Availability of data and materials
benign prostatic hyperplasia
International Prostate Symptom Score
AUA Practice Guidelines Committee (2003) AUA guideline on management of benign prostatic hyperplasia. Chapter 1: diagnosis and treatment recommendations. J Urol 170:530–547
Fishman JR, Merrill DC (1993) A case of giant prostatic hyperplasia. Urology 42:336–337
Medina PM, Valero PJ, Valpuesta FI (1997) Giant hypertrophy of the prostate: 2410 grams of weight and 24 cm in diameter. Arch Esp Urol 50:79–97
Tolley DA, English PJ, Grigor KM (1987) Massive benign prostatic hyperplasia. J R Soc Med 80:777–778
Ockerblad NF (1946) Giant prostate: the largest recorded. J Urol 56:81–82
Maliakal J, Mousa EE, Menon V (2014) Giant prostatic hyperplasia: fourth largest prostate reported in medical literature. Sultan Qaboos Univ Med J 14:253–256
Ucer O, Baser O, Gumus B (2011) Giant prostatic hyperplasia: case report and literature review. Dicle Med J 38:489–491
Hosseini SY, Safarinejad MR (2009) Huge benign prostatic hyperplasia. Urol J 4:276–277
Domínguez A, Gual J, Muñoz-Rodríguez J, Abad C et al (2016) Giant prostatic hyperplasia: case report of 3987 ml. Urology 88:3–4
Ethics approval and consent to participate
Our institution does not require ethical approval for this case report.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and accompanying images.
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Dincer, E., Ipek, O.M., Sarikaya Kayipmaz, S. et al. Giant prostatic hyperplasia: case presentation of the second largest prostate adenoma. Afr J Urol 27, 27 (2021). https://doi.org/10.1186/s12301-021-00131-3
- Benign prostatic hyperplasia
- Huge prostate
- Open surgery