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African Journal of Urology

Table 2 Low and favorable intermediate risk prostate cancer patients stratified by tumor load density (TLD) in the the surgical specimen (n = 433)

From: Endogenous testosterone density associates with predictors of tumor upgrading and disease progression in the low through favorable intermediate prostate cancer risk categories: analysis of risk factors and clinical implications

 

TLD up to 0.25

TLD > 0.25

P-value

Multivariable model I

Multivariable model II

Number

106

327

 

OR (95% CI)

P-value

OR (95% CI)

P-value

Clinical features

   

Clinical

 

Overall

 

Age (years), median (IQR)

66 (62–71)

65 (60–69)

0.002

0.940 (0.903–0.978)

0.002

0.924 (0.885–0.964)

 < 0.0001

BMI (kg/m2), median (IQR)

25.9 (23.5–28.1)

25.6 (23.8–27.7)

0.487

    

ET (ng/dL), median (IQR)

376.5 (295.5–531.0)

410 (315–504)

0.451

    

ETD (ng/(dL x mL)), median (IQR)

7.6 (5.5–10.5)

11.3 (7.8–15.5)

 < 0.0001

1.068 (1.108–1.121)

0.007

1.069 (1.015–1.125)

0.011

PSA (ng/mL), median (IQR)

5.6 (4.3–7.8)

5.9 (4.5–7.3)

0.935

    

PSAD (ng/(mL x mL)), median (IQR)

0.11 (0.07–0.15)

0.15 (0.11–0.21)

 < 0.0001

    

PSAD < 0.15, n (%)

76 (71.6)

146 (44.6)

 < 0.0001

Ref.

 

Ref.

 

PSAD > 0.14, n (%)

30 (28.3)

181 (55.4)

 

2.222 (1.317–3.749)

0.003

2.059 (1.197–3.542)

0.009

PV (mL), median (IQR)

50 (40–61.2)

37 (28–47)

 < 0.0001

    

BPC (%), median (IQR)

20 (14–33)

31 (21–50)

 < 0.0001

1.025 (1.011–1.040)

0.035

1.023 (1.009–1.038)

0.001

BPCD (%/mL), median (IQR)

0.40 (0.25–0.75)

0.86 (0.51–1.42)

 < 0.0001

    

ASA, n (%)

  

0.466

    

ASA 1

8 (7.5)

38 (11.6)

     

ASA 2

90 (84.9)

262 (80.1)

     

ASA 3

8 (7.5)

27 (8.3)

     

cT, n (%)

  

0.09

    

cT1c

85 (80.2)

235 (71.9)

     

cT 2a/2b

21 (19.28)

92 (28.2)

     

ISUP, n (%)

  

0.006

    

ISUP 1

65 (61.3)

150 (45.9)

 

Ref.

 

Ref.

 

ISUP 2

41 (38.7)

177 (54.1)

 

1.667 (1.038–2.708)

0.022

removed by model

 

Pathological features

   

Pathological

   

PW (grams; gr), median (IQR)

67.5 (52.7–78)

49 (40–60)

 < 0.0001

    

TL (%), median (IQR)

5 (5–10)

20 (15–30)

 < 0.0001

    

TLD (%/gr), median (IQR)

0.09 (0.07–0.12)

0.38 (0.25–0.62)

 < 0.0001

    

ISUP, n (%)

  

 < 0.0001

    

ISU p < 3

83 (78.3)

182 (55.7)

 

Ref.

 

Ref.

 

ISUP > 2

23 (21.7)

145 (44.3)

 

2.395 (1.416–4.051)

0.001

2.563 (1.460–4.500)

0.001

pT, n (%)

  

 < 0.0001

    

pT2

101 (95.3)

270 (82.6)

 

Ref.

 

Ref.

 

pT3a/b

5 (4.7)

57 (17.4)

 

2.766 (1.040–2.354)

0.041

2.875 (1.014–8.150)

0.047

SM, n (%)

  

0.039

    

NSM

88 (83)

239 (73.1)

 

Ref.

   

PSM

18 (17)

88 (26.9)

 

1.457 (0.813–2.612)

0.207

  
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