Table 4 Univariate and multivariate analyses of prognostic factors for disease progression by cox proportional hazards model

Age*

 ≤ 55 years

1.108 (0.224–5.490)

0.900

–

–

 > 55 years

Gender

Male

1.118 (0.131–9.570)

0.919

–

–

Female

Tobacco exposure

No

2.508 (0.293–21.482)

0.401

–

–

Yes

Grade

Low

0.532 (0.062–4.554)

0.564

–

–

High

Post-op intravesical therapy

No

1.301 (0.263–6.448)

0.747

–

–

Yes

Size

 ≤ 3 cm

12.144 (1.418–104.030)

0.043

1.248 (0.056–27.693)

0.889

 > 3 cm

T stage

Ta or Tis

22.090 (0.000–6.119)

0.683

–

–

T1N0M0

Number

Single

1.151 (0.232–5.704)

0.863

–

–

Multiple

Urine Cytology (pre-operative)

Positive

3.095 (0.361–26.497)

0.302

–

–

Negative

Pre-operative Plasma Fibrinogen (mg/dl)

 ≤ 402.50

30.232 (4.141–220.720)

0.001

33.726 (1.507–754.825)

0.027

 > 402.50

Pre-operative D-dimer (µg/ml)

 ≤ 0.55

917.840 (0.004–2.240)

0.028

5.590 (0.000–5.912)

0.042

 > 0.55