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Fig. 2 | African Journal of Urology

Fig. 2

From: The curious case of testicular descent: factors controlling testicular descent with a note on cryptorchidism

Fig. 2

Diagrammatic schema showing the hormonal factors influencing the testicular descent. A Shows early gonadal position in gonadal ridge. In the male foetus, MIH and testosterone causes the regression of the embryonic müllerian duct and regression of CSL, respectively. B MIH or Testosterone amplifies the action of INSL3 which stimulates gubernaculum enlargement. Descending is proposed to cause selective growth of gubernacular mesenchymal cells which might aid in testicular descent. C Androgens via CGRP released by the GFN influences the gubernacular migration and elongation in the inguinoscrotal phase

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