Table 3 Subgroup analysis of MTHFR polymorphisms rs1801133 and rs1801131
SNPs | Genetic model | Group | Number of studies | Asso P-val | OR 95% CI |
|---|---|---|---|---|---|
Rs1801133 | Geographic region | ||||
T vs. C | Western Asia | 1 | 0.016 | 2.36 [1.168–4.779] | |
TT vs. TC + CC | North African | 3 | 0.013 | 0.52 [0.311–0.872] | |
TT + TC vs. CC | South America | 1 | 0.046 | 0.56 [0.320–0.990] | |
Western Asia | 1 | 0.036 | 2.38 [1.055–5.400] | ||
South America | 1 | 0.033 | 0.556 [0.323–0.956] | ||
TT vs. TC | North African | 3 | 0.003 | 0.448 [0.261–0.769] | |
TC vs. CC | South America | 1 | 0.026 | 0.506 [0.277–0.923] | |
Genotyping methods | |||||
TC vs. CC | PCR–RFLP | 12 | 0.040 | 1.12 [1.005–1.269] | |
Rs1801131 | Geographic region: | ||||
CC + CA vs. AA | North African | 1 | 0.047 | 1.68 [1.006–2.832] | |
CC vs. CA | North American | 3 | 0.039 | 0.71 [0.523–0.984] | |
CA vs. AA | North African | 1 | 0.025 | 1.86 [1.079–3.210] | |
Genotyping methods | |||||
C vs. A | PCR-Sequencing | 1 | 0.004 | 0.69 [0.537–0.892] | |
CC vs. CA + AA | Taqman SNP genotyping assays | 1 | 0.027 | 0.48 [0.250–0.920] | |
CC + CA vs. AA | PCR-Sequencing | 1 | 0.003 | 0.53 [0.347–0.815] | |
CC vs. AA | PCR-Sequencing | 1 | 0.003 | 0.45 [0.269–0.777] | |
CC vs. CA | Taqman SNP genotyping assays | 1 | 0.011 | 0.419 [0.213–0.824] | |
CA vs. AA | PCR-Sequencing | 1 | 0.013 | 0.56 [0.364–0.890] |