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Table 2 Meta-analysis of the association between polymorphisms of genes MTHFR, DNMTs and bladder cancer susceptibility

From: A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

SNPs

Association test

Heterogeneity

Publication bias

Genetic models

OR

95% CI

p-value

Effect model

P-value*

I2

**Egger’s test p-value

MTHFR rs1801133

T vs. Ca

1.021

[0.927–1.124]

0.666

REM

0.013

0.485

0.630

TT vs. TC + CCb

0.962

[0.802–1.154]

0.682

REM

0.093

0.328

0.936

TT + TC vs. CCc

1.057

[0.936–1.194]

0.366

REM

0.035

0.420

0.397

TT vs. CCd

0.988

[0.798–1.223]

0.914

REM

0.032

0.427

0.869

TT vs. TCe

0.949

[0.826–1.092]

0.470

FEM

0.203

0.215

0.825

TC vs. CCf

1.058

[0.966–1.158]

0.219

FEM

0.118

0.299

0.394

MTHFR rs1801131

C vs. Aa

1.029

[0.870–1.215]

0.736

REM

0

0.741

0.787

CC vs. CA + AAb

0.889

[0.689–1.147]

0.368

REM

0.092

0.373

0.926

CC + CA vs. AAc

1.083

[0.867–1.354]

0.480

REM

0

0.745

0.867

CC vs. AA d

0.922

[0.637–1.334]

0.667

REM

8e−04

0.653

0.991

CC vs.CA e

0.845

[0.694–1.029]

0.094

FEM

0.557

0

0.594

CA vs. AA f

1.115

[0.902–1.380]

0.311

REM

2e−04

0.695

0.814

MTHFR rs2274976

A vs. Ga

1.044

[0.714–1.528]

0.820

FEM

0.77

0

AA vs. AG + GGb

2.020

[0.365–11.157]

0.419

FEM

AA + AG vs. GGc

1.007

[0.671–1.512]

0.972

FEM

0.87

0

AA vs. GGd

2.012

[0.363–11.140]

0.423

FEM

AA vs. AGe

2.058

[0.353–11.988]

0.421

FEM

AG vs. GGf

0.971

[0.641–1.470]

0.889

FEM

0.97

0

DNMT3A rs1550117

A vs. Ga

0.804

[0.632–1.021]

0.074

FEM

0.712

0

AA vs. AG + GGb

0.720

[0.344–1.507]

0.384

FEM

0.773

0

AA + AG vs. GGc

0.780

[0.590–1.030]

0.080

FEM

0.744

0

AA vs. GGd

0.668

[0.317–1.407]

0.289

FEM

0.746

0

AA vs. AGe

0.842

[0.392–1.810]

0.660

FEM

0.826

0

AG vs. GGf

0.794

[0.595–1.059]

0.116

FEM

0.800

0

DNMT3B rs1569686

G vs. Ta

0.882

[0.614–1.267]

0.499

FEM

0.984

0

GG vs. GT + TTb

0.245

[0.030–1.971]

0.186

FEM

0.890

0

GG + GT vs. TTc

0.949

[0.649–1.390]

0.791

FEM

0.944

0

GG vs. TT d

0.246

[0.030–1.979]

0.187

FEM

0.893

0

GG vs. GTe

0.237

[0.028–1.958]

0.181

FEM

0.872

0

GT vs. TT f

1.026

[0.698–1.507]

0.896

FEM

0.875

0

  1. REM random effect model, FEM fixed effect model
  2. *REM if p-value < 0.1, FEM if otherwise
  3. **p-value > 0.05 indicate that there is no publication bias
  4. aAllele contrast
  5. bRecessive model
  6. cDominant model
  7. dHomozygote model (homozygous rare vs. homozygous frequent allele)
  8. eHomozygous rare vs. Heterozygous
  9. fHeterozygote model (heterozygous vs. homozygous frequent allele)