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Table 2 Meta-analysis of the association between polymorphisms of genes MTHFR, DNMTs and bladder cancer susceptibility

From: A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

SNPs Association test Heterogeneity Publication bias
Genetic models OR 95% CI p-value Effect model P-value* I2 **Egger’s test p-value
MTHFR rs1801133
T vs. Ca 1.021 [0.927–1.124] 0.666 REM 0.013 0.485 0.630
TT vs. TC + CCb 0.962 [0.802–1.154] 0.682 REM 0.093 0.328 0.936
TT + TC vs. CCc 1.057 [0.936–1.194] 0.366 REM 0.035 0.420 0.397
TT vs. CCd 0.988 [0.798–1.223] 0.914 REM 0.032 0.427 0.869
TT vs. TCe 0.949 [0.826–1.092] 0.470 FEM 0.203 0.215 0.825
TC vs. CCf 1.058 [0.966–1.158] 0.219 FEM 0.118 0.299 0.394
MTHFR rs1801131
C vs. Aa 1.029 [0.870–1.215] 0.736 REM 0 0.741 0.787
CC vs. CA + AAb 0.889 [0.689–1.147] 0.368 REM 0.092 0.373 0.926
CC + CA vs. AAc 1.083 [0.867–1.354] 0.480 REM 0 0.745 0.867
CC vs. AA d 0.922 [0.637–1.334] 0.667 REM 8e−04 0.653 0.991
CC vs.CA e 0.845 [0.694–1.029] 0.094 FEM 0.557 0 0.594
CA vs. AA f 1.115 [0.902–1.380] 0.311 REM 2e−04 0.695 0.814
MTHFR rs2274976
A vs. Ga 1.044 [0.714–1.528] 0.820 FEM 0.77 0
AA vs. AG + GGb 2.020 [0.365–11.157] 0.419 FEM
AA + AG vs. GGc 1.007 [0.671–1.512] 0.972 FEM 0.87 0
AA vs. GGd 2.012 [0.363–11.140] 0.423 FEM
AA vs. AGe 2.058 [0.353–11.988] 0.421 FEM
AG vs. GGf 0.971 [0.641–1.470] 0.889 FEM 0.97 0
DNMT3A rs1550117
A vs. Ga 0.804 [0.632–1.021] 0.074 FEM 0.712 0
AA vs. AG + GGb 0.720 [0.344–1.507] 0.384 FEM 0.773 0
AA + AG vs. GGc 0.780 [0.590–1.030] 0.080 FEM 0.744 0
AA vs. GGd 0.668 [0.317–1.407] 0.289 FEM 0.746 0
AA vs. AGe 0.842 [0.392–1.810] 0.660 FEM 0.826 0
AG vs. GGf 0.794 [0.595–1.059] 0.116 FEM 0.800 0
DNMT3B rs1569686
G vs. Ta 0.882 [0.614–1.267] 0.499 FEM 0.984 0
GG vs. GT + TTb 0.245 [0.030–1.971] 0.186 FEM 0.890 0
GG + GT vs. TTc 0.949 [0.649–1.390] 0.791 FEM 0.944 0
GG vs. TT d 0.246 [0.030–1.979] 0.187 FEM 0.893 0
GG vs. GTe 0.237 [0.028–1.958] 0.181 FEM 0.872 0
GT vs. TT f 1.026 [0.698–1.507] 0.896 FEM 0.875 0
  1. REM random effect model, FEM fixed effect model
  2. *REM if p-value < 0.1, FEM if otherwise
  3. **p-value > 0.05 indicate that there is no publication bias
  4. aAllele contrast
  5. bRecessive model
  6. cDominant model
  7. dHomozygote model (homozygous rare vs. homozygous frequent allele)
  8. eHomozygous rare vs. Heterozygous
  9. fHeterozygote model (heterozygous vs. homozygous frequent allele)