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Table 1 The main characteristics of the 20 studies included in the meta-analysis

From: A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

Study ID Study population Geographic region Source of control Genotyping Techniques Gene SNPs Cases/controls HWE Quality score
*P-value **Adjusted P- value  
Chung 2014a[17] Tawian East Asian HB PCR–RFLP
PCR–RFLP
DNMT3A
DNMT3B
rs1550117
rs1569686
170/ 331
163/ 328
0.7901
0.5699
0.8426
0.5699
8
Chung 2014b [16] Taiwan East Asian HB PCR–RFLP DNMT3B rs1569686 159/308 0.0912 0.1824 5
Karagas et al. 2005[15] New Hamsphire /USA North American PB PCR–RFLP MTHFR rs1801133
rs1801131
350/543
350/542
0.7019
0.3333
0.8523
0.5259
11
Izmirli et al. 2011[18] Turkey West Asian HB PCR–RFLP MTHFR rs1801133
rs1801131
54/50
47/50
0.2497
0.1952
0.6226
0.4228
2
Ouerhani et al. 2009 [19] Tunisia North African NA PCR–RFLP MTHFR rs1801133 90/110 0.4167 0.7084 4
Cai et al. 2009 [20] China East Asian HB PCR–RFLP MTHFR rs1801133
rs1801131
312/325
312/325
0.0755
0.5043
0.3808
0.6052
7
Ouerhani et al. 2007 [21] Tunisia North African NA PCR–RFLP MTHFR rs1801133
rs1801131
111/131
111/131
0.5502
0.0891
0.7258
0.4032
4
Beebe-Dimmer et al. 2012 [22] Southeastern-Michigen /USA North American PB Taqman SNP genotyping assays MTHFR rs1801133
rs1801131
219/273
218/272
0.9281
0.2114
0.9281
0.4228
8
Lin et al. 2004 [23] USA North American HB PCR–RFLP MTHFR rs1801133
rs1801131
410/410
410/409
0.0896
0.3506
0.3808
0.5259
8
Safarinejad et al. 2011 [24] Iran South Asian HB PCR–RFLP MTHFR rs1801133
rs1801131
rs2274976
158/316
158/316
158/316
0.555
0.4601
0.4276
0.7258
0.6052
0.8552
8
Moore et al. 2004 [25] Argentina South American PB NA MTHFR rs1801133
rs1801131
106/109
106/108
0.293
0.7708
0.6226
0.7708
7
Kimura et al. 2001 [26] Germany Western Europe HB NA MTHFR rs1801133 165/150 0.1695 0.5763 3
Chung et al. 2010 [27] Taiwan East Asian HB PCR–RFLP MTHFR rs1801133 150/300 0.2564 0.6226 8
Sanyal et al. 2004 [28] Sweden Northern Europe PB PCR–RFLP MTHFR rs1801133
rs1801131
309/246
311/245
0.8225
0.6005
0.9125
0.6551
7
Gautam et al. 2019 [29] India South Asian NA PCR-Sequencing MTHFR rs1801133
rs1801131
232/250
232/250
0.3982
0.1008
0.7084
0.4032
7
Wang et al. 2009 [30] China East Asian HB PCR–RFLP MTHFR rs1801133
rs1801131
239/250
239/250
0.0665
0.1869
0.3808
0.4228
9
Tsai et al. 2014 [31] Taiwan East Asian NA PCR–RFLP DNMT3A rs1550117 168/332 0.8426 0.8426 5
Moore et al. 2007 [32] Spain Southern Europe HB NA MTHFR rs1801133 1041/1049 0.4807 0.7258 9
Kherouatou-Chaoui et al. 2015[33] Algeria North African NA PCR–RFLP MTHFR rs1801133 95/109 0.0282 0.3808 5
Ali 2012 [34] Pakistan South Asian PB PCR–RFLP MTHFR rs1801133
rs1801131
rs2274976
200/200
200/200
200/200
0.8588
0.0113
0.9368
0.9125
0.1356
0.9368
10
  1. PB population based, HB hospital based, HWE Hardy–Weinberg equilibrium; *Unadjusted HWE p-values; **Adjusted HWE p-values by FDR method. NA not available, DNMT3A DNA (cytosine-5)-methyltransferase 3 alpha, DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta, PCR–RFLP polymerase chain reaction-restriction fragment length polymorphism, MTHFR: 5,10-méthylènetétrahydrofolate reductase, SNP single nucleotide polymorphism