A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

Touala-Chaila, Zohra; Abderrahmane, Rym-Khadidja; Benseddik, Khedidja; Meroufel, Djebaria Naima

doi:10.1186/s12301-022-00301-x

African Journal of Urology

Table 1 The main characteristics of the 20 studies included in the meta-analysis

From: A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

Study ID	Study population	Geographic region	Source of control	Genotyping Techniques	Gene	SNPs	Cases/controls	HWE		Quality score
Study ID	Study population	Geographic region	Source of control	Genotyping Techniques	Gene	SNPs	Cases/controls	*P-value	**Adjusted P- value
Chung 2014a[17]	Tawian	East Asian	HB	PCR–RFLP PCR–RFLP	DNMT3A DNMT3B	rs1550117 rs1569686	170/ 331 163/ 328	0.7901 0.5699	0.8426 0.5699	8
Chung 2014b [16]	Taiwan	East Asian	HB	PCR–RFLP	DNMT3B	rs1569686	159/308	0.0912	0.1824	5
Karagas et al. 2005[15]	New Hamsphire /USA	North American	PB	PCR–RFLP	MTHFR	rs1801133 rs1801131	350/543 350/542	0.7019 0.3333	0.8523 0.5259	11
Izmirli et al. 2011[18]	Turkey	West Asian	HB	PCR–RFLP	MTHFR	rs1801133 rs1801131	54/50 47/50	0.2497 0.1952	0.6226 0.4228	2
Ouerhani et al. 2009 [19]	Tunisia	North African	NA	PCR–RFLP	MTHFR	rs1801133	90/110	0.4167	0.7084	4
Cai et al. 2009 [20]	China	East Asian	HB	PCR–RFLP	MTHFR	rs1801133 rs1801131	312/325 312/325	0.0755 0.5043	0.3808 0.6052	7
Ouerhani et al. 2007 [21]	Tunisia	North African	NA	PCR–RFLP	MTHFR	rs1801133 rs1801131	111/131 111/131	0.5502 0.0891	0.7258 0.4032	4
Beebe-Dimmer et al. 2012 [22]	Southeastern-Michigen /USA	North American	PB	Taqman SNP genotyping assays	MTHFR	rs1801133 rs1801131	219/273 218/272	0.9281 0.2114	0.9281 0.4228	8
Lin et al. 2004 [23]	USA	North American	HB	PCR–RFLP	MTHFR	rs1801133 rs1801131	410/410 410/409	0.0896 0.3506	0.3808 0.5259	8
Safarinejad et al. 2011 [24]	Iran	South Asian	HB	PCR–RFLP	MTHFR	rs1801133 rs1801131 rs2274976	158/316 158/316 158/316	0.555 0.4601 0.4276	0.7258 0.6052 0.8552	8
Moore et al. 2004 [25]	Argentina	South American	PB	NA	MTHFR	rs1801133 rs1801131	106/109 106/108	0.293 0.7708	0.6226 0.7708	7
Kimura et al. 2001 [26]	Germany	Western Europe	HB	NA	MTHFR	rs1801133	165/150	0.1695	0.5763	3
Chung et al. 2010 [27]	Taiwan	East Asian	HB	PCR–RFLP	MTHFR	rs1801133	150/300	0.2564	0.6226	8
Sanyal et al. 2004 [28]	Sweden	Northern Europe	PB	PCR–RFLP	MTHFR	rs1801133 rs1801131	309/246 311/245	0.8225 0.6005	0.9125 0.6551	7
Gautam et al. 2019 [29]	India	South Asian	NA	PCR-Sequencing	MTHFR	rs1801133 rs1801131	232/250 232/250	0.3982 0.1008	0.7084 0.4032	7
Wang et al. 2009 [30]	China	East Asian	HB	PCR–RFLP	MTHFR	rs1801133 rs1801131	239/250 239/250	0.0665 0.1869	0.3808 0.4228	9
Tsai et al. 2014 [31]	Taiwan	East Asian	NA	PCR–RFLP	DNMT3A	rs1550117	168/332	0.8426	0.8426	5
Moore et al. 2007 [32]	Spain	Southern Europe	HB	NA	MTHFR	rs1801133	1041/1049	0.4807	0.7258	9
Kherouatou-Chaoui et al. 2015[33]	Algeria	North African	NA	PCR–RFLP	MTHFR	rs1801133	95/109	0.0282	0.3808	5
Ali 2012 [34]	Pakistan	South Asian	PB	PCR–RFLP	MTHFR	rs1801133 rs1801131 rs2274976	200/200 200/200 200/200	0.8588 0.0113 0.9368	0.9125 0.1356 0.9368	10

PB population based, HB hospital based, HWE Hardy–Weinberg equilibrium; *Unadjusted HWE p-values; **Adjusted HWE p-values by FDR method. NA not available, DNMT3A DNA (cytosine-5)-methyltransferase 3 alpha, DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta, PCR–RFLP polymerase chain reaction-restriction fragment length polymorphism, MTHFR: 5,10-méthylènetétrahydrofolate reductase, SNP single nucleotide polymorphism

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