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Table 3 Comparison between methylation status in bladder biopsies and voided urine sediments

From: Exploring urine sediments as a non-invasive method for DNA methylation detection in bladder cancer

Genes Hypermethylation detection in fresh tumor biopsies Hypermethylation detection in urine sediments Sensitivity % (95% CI)
N % [95% CI] N % [95% CI]
TWIST1 36 90 [76.3–97.2] 33 82.5 [67.2–92.7] 91.7 [77.5–98.2]
hTERT 34 85 [70.2–94.3] 33 82.5 [67.2–92.7] 97.1 [84.7–99.9]
NID2 25 62.5 [45.8–77.3] 21 52.5 [36.1–68.5] 84 [63.9–95.5]
VIM 29 72.5 [56.1–85.4] 24 60 [43.3–75.1] 82.8 [64.2–94.2]
  1. CI = confidence interval