Table 3 Comparison between methylation status in bladder biopsies and voided urine sediments
From: Exploring urine sediments as a non-invasive method for DNA methylation detection in bladder cancer
Genes | Hypermethylation detection in fresh tumor biopsies | Hypermethylation detection in urine sediments | Sensitivity % (95% CI) | ||
|---|---|---|---|---|---|
N | % [95% CI] | N | % [95% CI] | ||
TWIST1 | 36 | 90 [76.3–97.2] | 33 | 82.5 [67.2–92.7] | 91.7 [77.5–98.2] |
hTERT | 34 | 85 [70.2–94.3] | 33 | 82.5 [67.2–92.7] | 97.1 [84.7–99.9] |
NID2 | 25 | 62.5 [45.8–77.3] | 21 | 52.5 [36.1–68.5] | 84 [63.9–95.5] |
VIM | 29 | 72.5 [56.1–85.4] | 24 | 60 [43.3–75.1] | 82.8 [64.2–94.2] |