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Table 2 Study characteristics and results

From: Efficacy of holmium laser enucleation of the prostate in patients with detrusor underactivity: systematic review and meta-analysis

Author

Study Design

Location

Sample Numbers

Exposure

Comparator

Outcome

Results

Pyun et al. (2017) [12]

Retrospective Cohort

South Korea

227 patients

Patients with detrusor dysfunction (56 with detrusor overactivity and 33 with detrusor underactivity) that underwent HoLEP (n = 89)

Patients only with bladder outlet obstruction (BOO) (n = 138)

IPSS, Quality of Life, Qmax, and PVR

Patients in BOO-only group had greater IPSS improvement than detrusor dysfunction group (p = 0.023). Post-operative IPSS voiding (4.5 vs 7.0) and Qmax (18 vs 13.7) is significantly better in BOO-only group than detrusor underactivity group

Choi et al. (2011) [13]

Retrospective Cohort

South Korea

371 patients

Patients with bladder outlet obstruction (BOO) and detrusor underactivity (DU) that underwent PVP (n = 132)

Patients with bladder outlet obstruction (BOO) that underwent PVP (n = 132)

IPSS, Qmax, and PVR

There is no significant difference in group with DU or not in outcome parameter at 1 and 12 months after the operation

Cho et al. (2016) [14]

Retrospective Cohort

South Korea

1423 patients

Holmium laser enucleation of the prostate (HoLEP) divided into groups without detrusor underactivity (B1) (n = 329) or with detrusor underactivity (B2) (n = 423)

Photoselective vaporisation of the prostate (PVP) divided into groups without detrusor underactivity (A1) (n = 239) or with detrusor underactivity (A2) (n = 432)

IPSS, uroflowmetry component (Qmax and PVR) and prostate-specific antigen (PSA)

After one month follow up, A1 and BI group had higher increases in maximum flow rate than A2 or B2. B2 had better improvements in maximum flow rate and IPSS score than A2

Woo et al. (2017) [15]

Retrospective Cohort

South Korea

56 patients

Holmium laser enucleation of the prostate (HoLEP) n = 24)

Transurethral resection of prostate (TURP) (n = 32)

IPSS, Qmax, and PVR

After six months follow up, HoLEP group subjects had higher Qmax (p = 0.005) and lower PVR values (P = 0.022) than TURP group

Jaeger et al. (2014) [16]

Retrospective Cohort

United States of America

103 patients

Holmium laser enucleation of the prostate (HoLEP) (n = 72)

Photoselective vaporisation of the prostate (PVP) (n = 31)

AUA Symptom Index (AUASI), Qmax, PVR, catheter-free rate

After six months follow up, HoLEP group subjects (99%) had higher catheter-free rate (p < 0.01) than PVP group (74%). There was improvement in AUASI, maximum urinary flow rate and PVR in both groups