Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of prostate cancer in Algerian population

African Journal of Urology

Table 4 Correlation between GSTM1, GSTT1, CYP1A1 genotypes and different Gleason scores

Polymorphism	Gleason score		OR/CI	P value
	GS ≤ 7	GS > 7
	(n = 37)	(n = 64)
GSTM1
M+	17 (45.94%)	26 (40.62%)	0.89 [0.69–1.15]	0.40
M−	20 (54.05%)	38 (59.38%)	0.89 [0.69–1.15]	0.40
GSTT1
T+	26 (70.27%)	37 (57.81%)	0.91 [0.70–1.17]	0.47
T−	11 (29.72%)	27 (42.19%)	0.91 [0.70–1.17]	0.47
GSTM1/GSTT1
Both present	13 (35.14%)	17 (26.57%)
Either null	17 (45.94%)	29 (45.31%)	0.92 [0.71–1.18]	0.52
Both null	7 (18.92%)	18 (28.12%)	0.87 [0.66–1.14]	0.31
CYP1A1
TT	29 (78.37%)	53 (82.21%)	0.78 [0.56–1.07]	0.13
TC	8 (21.63%)	11 (17.19%)	0.78 [0.56–1.07]	0.13