Table 2 Antibiotic prophylaxis protocols and incidence of sepsis after TRUS-PB in contemporary reports

Rumaihi et al. [20]

G 1: Ciprofloxacin 500 mg 2 days before the procedure and 3 days after

G 2: The same + Cefuroxime 1.5 g IV 30 min before the procedure

G 1: 8.8%

G 2: 3.6%

Manecksha et al. [11]

G 1: Ofloxacin 400 mg immediately before the procedure and 200 mg twice daily 3 days after

G2: Ofloxacin 200 mg twice daily for 3 days commencing 24 h before the procedure

G 1: 3.6%

G2: 1.6%

Kehinde et al. [17]

G 1: Ciprofloxacin 500 mg twice daily 1 day the procedure and 2 days after

G 2: the same + IV Amikacin 500 mg 30 min before the procedure

G 1: 8%

G 2: 1.7%

Rudziniski et al. [14]

3-day course of oral antibiotic prior to the biopsy

2.2%

Singh et al. [7]

According to rectal swab

 Fluoroquinolone sensitive;

 Oral Ciprofloxacin 500 mg + Tinidazole 600 mg

 Fluoroquinolone resistant;

Culture directed antibiotics

0%

El Shal et al. [15]

Standard prophylaxis

 Ciprofloxacin 500 mg BD 3 days starting the night of the biopsy

Augmented Prophylaxis

 Ciprofloxacin + Single dose of gentamicin 160 mg IM at the biopsy

Targeted prophylaxis

 According to rectal swab culture

2%

0.6%

4.3%

Present study 2018

G 1: 1 g Amikacin 30 min before the biopsy and ciprofloxacin 500 mg oral immediately after the procedure for 5 days

G 2: The same as Group 1 + Ciprofloxacin started 1 day before the biopsy

G1: 5.6%

G2: 1.1%