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Table 2 Antibiotic prophylaxis protocols and incidence of sepsis after TRUS-PB in contemporary reports

From: Antibiotic prophylaxis for transrectal ultrasound-guided prostatic biopsies: a comparison of two regimens

ReferenceNo. of patientsAntibiotic policySepsis  %
Rumaihi et al. [20]455G 1: Ciprofloxacin 500 mg 2 days before the procedure and 3 days after
G 2: The same + Cefuroxime 1.5 g IV 30 min before the procedure
G 1: 8.8%
G 2: 3.6%
Manecksha et al. [11]1183G 1: Ofloxacin 400 mg immediately before the procedure and 200 mg twice daily 3 days after
G2: Ofloxacin 200 mg twice daily for 3 days commencing 24 h before the procedure
G 1: 3.6%
G2: 1.6%
Kehinde et al. [17]1197G 1: Ciprofloxacin 500 mg twice daily 1 day the procedure and 2 days after
G 2: the same + IV Amikacin 500 mg 30 min before the procedure
G 1: 8%
G 2: 1.7%
Rudziniski et al. [14]9273-day course of oral antibiotic prior to the biopsy2.2%
Singh et al. [7]247According to rectal swab
 Fluoroquinolone sensitive;
 Oral Ciprofloxacin 500 mg + Tinidazole 600 mg
 Fluoroquinolone resistant;
Culture directed antibiotics
0%
El Shal et al. [15]469Standard prophylaxis
 Ciprofloxacin 500 mg BD 3 days starting the night of the biopsy
Augmented Prophylaxis
 Ciprofloxacin + Single dose of gentamicin 160 mg IM at the biopsy
Targeted prophylaxis
 According to rectal swab culture
2%
0.6%
4.3%
Present study 2018146G 1: 1 g Amikacin 30 min before the biopsy and ciprofloxacin 500 mg oral immediately after the procedure for 5 days
G 2: The same as Group 1 + Ciprofloxacin started 1 day before the biopsy
G1: 5.6%
G2: 1.1%
  1. G 1 Group 1, G 2 Group 2